Computational Comparative Genomics : Genes , Regulation ,
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IEM: an algorithm for iterative enhancement of motifs using comparative genomics data.
Understanding gene regulation is a key step to investigating gene functions and their relationships. Many algorithms have been developed to discover transcription factor binding sites (TFBS); they are predominantly located in upstream regions of genes and contribute to transcription regulation if they are bound by a specific transcription factor. However, traditional methods focusing on finding...
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Transcriptional regulation is a major tier in the periodic engine that mobilizes cell cycle progression. The availability of complete genome sequences of multiple organisms holds promise for significantly improving the specificity of computational identification of functional elements. Here, we applied a comparative genomics analysis to decipher transcriptional regulatory elements that control ...
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MicroRNAs (miRNAs) are short, non-protein coding RNAs that direct the widespread phenomenon of post-transcriptional regulation of metazoan genes. The mature approximately 22-nt long RNA molecules are processed from genome-encoded stem-loop structured precursor genes. Hundreds of such genes have been experimentally validated in vertebrate genomes, yet their discovery remains challenging, and sub...
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Rapid accumulation of genomic sequences is giving us a new opportunity to investigate and understand intricate biological systems, which may be represented as networks of genes and gene products. Several new experimental methods such as DNA microarray technology would be utilized to produce a huge amount of expression profiles and to determine correlated expression of genes in a wide variety of...
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Since our last issue, several important genomes have been completely or 'almost completely' sequenced. The debate over the number of human genes has flared up once more, with one computational and one experimental study into the annotation of the human genome. The mouse genome project has a clone fingerprint map to aid their sequencing effort. The SAGE technique has been applied to Drosophila a...
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تاریخ انتشار 2003